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Eighth-seeded Andreas Seppi of Italy overcame first set deficit to beat Leonardo Mayer of Argentina 2-6 6-1 6-4 to advance into the second round of the Serbia Open on Tuesday.
Seppi next faces Frenchman Richard Gasquet, who cruised past Belgian Olivier Rochus 6-0 6-1 in just 54 minutes.
Defending champion and top seed Novak Djokovic will face Fabio Fognini in the second round after the Italian defeated Croatian qualifier Franco Skugor 6-3 6-1.
Djokovic younger brother Marko Djokovic lost to Italian qualifier Alessio Di Mauro 6-7(5) 7-5 6-0.
“Of course I'm disappointed. I had my chances and couldn't take them. A win in today's match would have meant a lot" said younger Djokovic.
Another teenager Serbian wild card Filip Krajinovic earned his first win on tour as he prevailed 5-7 7-6(7) 6-1 against teenager Evgeny Donskoy of Russia.
Frenchman Josselin Ouanna eased past Italian qualifier Flavio Cipolla 6-3 6-1 to set up next round clash with second seeded American John Isner.